SULT2A1 and wet macular degeneration: For two AMD subtypes, the IVW estimates indicated that 1-stearoyl-GPE (18:0) (OR = 0.79, p < 0.001) exhibited protective effects on dry AMD; 1-stearoyl-GPE (18:0) (OR = 0.81, p = 0.003), androstenediol (3β,17β) monosulfate (OR = 0.75, p < 0.001), xylose (OR = 0.72, p < 0.001), DHEAS (OR = 0.76, p < 0.001), 5α-androstan-3β,17β-diol disulfate (OR = 0.80, p < 0.001), and N2-acetyl, N6, N6-dimethyllysine (OR = 0.91, p = 0.002) decreased the risk of wet AMD, while 16a-hydroxy DHEA 3-sulfate (OR = 1.20, p = 0.001) and succinimide(OR = 1.23, p = 0.001) increased the risk of wet AMD.