The same pattern of downregulation of SOST was seen for the hyperhomocysteinemia induced osteoclast model for taurine individually and in combination with vitamin B12 with the combination dose of 200 mM taurine and 0.5 mM vitamin B12 showing the most efficacy in alleviating the osteoporotic conditions rendered by excessive homocysteine accumulation within the cells. Here, SOST is linked to hyperhomocysteinemia.