The initial human-like tauopathy in R955-hTau+/− rats was previously evidenced by a subtle increase in ptau Ser202-Thr205 (AT8 monoclonal antibody (mAb)) IR after 18 M followed by a surge of ptau Ser202-Thr205, pThr231 and oligomeric tau after 24M [36]. Here, MAPT is linked to tauopathy.