In subjects with a history suggestive of clinically manifest IgE-mediated allergy, in which allergy tests are positive for both Vespidae and Apidae venom or for both Vespidae and Polistinae venom, in addition to a careful clinical history aimed at identifying which insect is most likely to have caused the reaction, the search for species-specific molecular allergens (Apidae: Api m 1, Api m 2, Api m 3, Api m 5, Api m 10; Vespidae: Ves v 1, Ves v 5; Polistinae: Pol d 5) may be very useful. This evidence concerns the gene IGHE and allergic disease.