GPT and neoplasm: This may be due to the fact that RFA is thermal ablation, and the corresponding cells are coagulative necrosis, resulting in the release of enzymes cannot into the blood vessels, so the increase of ALT and AST cannot be detected, while IRE is nonthermal ablation, which uses electric pulses to create nanopores in the cell membrane of the tumor cell, eventually causing the cell to undergo apoptosis mainly.