Statins also modulate the production of NO by iNOS, and its oxidative byproduct peroxynitrite in astrocytes is believed to be responsible for neuronal degeneration after ischemia and in many CNS disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), tumors, and trauma (Schmeer et al. 2006). Here, NOS2 is linked to ischemia.