Subsequently, Schisandrin A resists the occurrence of ferroptosis through Nrf2/HO-1/GPX4 on the one hand, and inhibits the TXNIP/NLRP3 pathway on the other hand, so as to play a role in treating DKD (X WangQ Li et al. 2022). The gene discussed is NFE2L2; the disease is diabetic kidney disease.