Syringaresinol inhibits the NLRP3/Caspase1/GSDMD pyroptosis pathway on the one hand, and on the other hand promotes the Nrf2 nuclear translocation to activate downstream HO-1 to produce antioxidation to jointly treat kidney injury in DKD mice (Li et al. 2023a). This evidence concerns the gene NFE2L2 and diabetic kidney disease.