Studies have shown that in HG-induced podocyte and in the glomeruli of DKD patients, there is a high positive expression of ubiquitin C-terminal hydrolase L1 (UCHL1), necroptosis signaling markers (RIPK1/3, MLKL), and apoptosis signaling markers (caspase-3). This evidence concerns the gene MLKL and diabetic kidney disease.