Ginsenoside compound K and Ginsenoside Rg5 share the same mechanism, regulating TXNIP and NOX4 in DKD mice, and inhibiting the phosphorylation of NF-κB p65 and p38 MAPK to further alleviate endothelial cell pyroptosis and delay the progress of DKD (Song et al. 2018a; Zhu et al. 2020). Here, TXNIP is linked to diabetic kidney disease.