CASP1 and diabetic kidney disease: This experiment explored a new relationship between glucose concentration and HK-2 cell pyroptosis, which is conducive to further research work (Liu et al. 2022c).The experiment of Yuan et al. further suggested that the renal tissues of patients with DKD Yuan et al. further suggested that GSDMD, caspase-1 and IL-1β, which are mainly located in the proximal tubules of the kidney, were elevated in renal tissues of DKD patients.