Wogonin upregulates Bcl-2, disrupts Bcl-2/Beclin1 binding, releases Beclin1, and mediates HG-induced autophagy and apoptosis crosstalk in MPC5 cells, reducing inflammation, apoptosis, and promoting autophagy to decelerate DKD progression (Liu et al. 2022b). The gene discussed is BECN1; the disease is diabetic kidney disease.