All three can inhibit the occurrence of pyroptosis in HG-induced cells mediated by the NLRP3/caspase-1/IL-1β/IL-18 pathway, and increase cell viability for the treatment of DKD (ChenWei et al. 2018; Ding et al. 2018; Lu et al. 2017). This evidence concerns the gene IL18 and diabetic kidney disease.