While Wang et al. found significant up-regulation of Circ_0004951 in renal tissues from DKD patients and HG-intervened HK-2 cells, further studies suggested that Circ_0004951 could down-regulate miR-93-5p expression to activate NLRP3-induced pyroptosis (Wang et al. 2022d). This evidence concerns the gene NLRP3 and diabetic kidney disease.