Cassia auricula ethyl leaf extract (CALE) can improve the dysfunction and structural abnormality of kidney injury in DKD rats by inhibiting autophagy and necrotizing apoptosis pathways, which is demonstrated by the reduction of LC3-II, RIPK1/3 and p38MAPK (Al Shahrani et al. 2021). This evidence concerns the gene RIPK1 and diabetic kidney disease.