The role of AMPK in regulating ferroptosis has been well-documented, with studies showing that energy–stress-mediated AMPK activation can inhibit ferroptosis (Lee et al. 2020; Zou et al. 2024), and that the LKB1-AMPK axis negatively regulates ferroptosis by inhibiting fatty acid synthesis (Kottakis and Bardeesy 2012; Li et al. 2020b) Our findings extend these insights by demonstrating that in GDM, GLUT1 upregulation disrupts this protective mechanism, leading to enhanced ferroptosis through ACC activation. Here, STK11 is linked to gestational diabetes.