GJA1 and glomerulonephritis: Thus, in hypertensive mice, Cx43 was highly increased within renal vasculature, following ureteral unilateral obstruction within the tubule-interstitial compartment, and after induction of experimental glomerulonephritis, Cx43 was increased in glomerular endothelial cells and de novo expressed in podocytes (Abed et al. 2014).