AKT1 and early-onset autosomal dominant Alzheimer disease: The KEGG enrichment analysis could be categorized into following aspects (Fig. 5B and C): Human Disease (Pathways in cancer, Lipid and atherosclerosis, Diabetic cardiomyopathy, Alzheimer disease and Endocrine resistance), Organismal systems (Immune system and Endocrine system), and Signal transduction (cAMP pathway, MAPK pathway, HIF-1 pathway, VEGF pathway, NF-kappa B pathway, PI3K/Akt pathway).