The main evidence supporting this view includes: (1) increased insulin secretion in UCP2 knockout mice (Zhang et al. 2001; Patanè et al. 2002), (2) elevated UCP2 expression levels strongly associated with high blood glucose levels (Brown et al. 2002), and (3) the therapeutic effect observed upon UCP2 knockout in mice modeling Type 2 diabetes (Zhang et al. 2001). Here, INS is linked to type 2 diabetes mellitus.