Interestingly, a greater degree of pancreatitis due to UCP2 knockout was observed only in aged UCP2-deficient mice (12 months old) and was more pronounced in the late stages of pancreatitis induction by sequential cerulein injections (24 h and 7 days after AP) (Segersvärd et al. 2005). This evidence concerns the gene UCP2 and pancreatitis.