INS and pancreas disorder: Given the significant role of the UCP2 gene in regulating energy homeostasis, ROS, insulin secretion, and overall metabolism, as well as its critical regulatory role in pancreatic diseases.ROS generated by metabolic stress in the mitochondria of β-cells activates several ROS-related signaling pathways, such as the AMP-activated protein kinase (AMPK), Wnt, and nuclear factor kappa B (NF-κB) (Beall et al. 2013; Wang et al. 2014; Yu et al. 2020).