CD53 and mast cell leukemia: Although the HMC-1 cell line, derived from a patient with mast cell leukemia, is widely utilized in studies of human MC functions due to its expression of cytokines or cell surface antigen profile (Fu et al. 2021; Sundstrom et al. 2003), as well as for exploring the underlying regulatory molecular mechanism in allergic responses (Fang et al. 2022; Hu et al. 2024), the responses to DEP and the underlying regulatory mechanisms observed in HMC-1 cells need to be further validated using human primary MCs in the future studies.