BBR could enter into the cytoplasm of CCD-18Co cells (Guan et al. 2018), increase p-Akt levels in the ovaries of letrozole-induced PCOS rats (Zhang et al. 2020b) and in the heart of LPS-induced septic mice (Zhang et al. 2022a). The gene discussed is AKT1; the disease is polycystic ovary syndrome.