IL18 and obesity due to melanocortin 4 receptor deficiency: We detected increased mRNA levels of NLPR3 (P = 0.002), NLRP6 (P < 0.001) and its effectors IL1B (P = 0.002), IL8 (P = 0.047) and IL18 (P = 0.006) in VAT of patients with obesity and with obesity and T2D (Fig. 2B–F).