Two important components of the inflammasomes, NLRP3 and NLRP6 together with their mediators IL1B and IL18 were upregulated in VAT of patients with obesity and obesity-associated T2D and were significantly associated with PIEZO1. It suggests that obesity-associated mechanical stress sensed by PIEZO1 leads to persistent Ca2+ influx, potentially contributing to sustained NLRP activation and chronic inflammation. Here, IL18 is linked to obesity due to melanocortin 4 receptor deficiency.