Since PIEZO1 is upregulated in the VAT from individuals with obesity and with obesity and T2D, mainly in adipocytes, we further analyzed the adipocyte-macrophage crosstalk by studying the effect of the adipocyte secretome obtained from patients with obesity in the expression of PIEZO1 in THP-1-derived macrophages. The gene discussed is PIEZO1; the disease is obesity due to melanocortin 4 receptor deficiency.