Since emerging evidence links PIEZO1-mediated mechanotransduction and signaling pathways to AT biology, inflammation and metabolic regulation, we hypothesize that PIEZO1 is dysregulated in visceral AT (VAT) in the context of obesity and obesity-associated T2D, being activated by mechanical forces and influencing the development of AT inflammation. This evidence concerns the gene PIEZO1 and obesity due to melanocortin 4 receptor deficiency.