INS and obesity due to melanocortin 4 receptor deficiency: We found increased SWELL1 mRNA levels in both groups of patients with obesity as well as a positive association with PIEZO1. Reportedly, SWELL1 is activated in the context of adipocyte hypertrophy in obesity being required for maintaining insulin signaling and glucose homeostasis by enhancing insulin-PI3K-AKT2 signaling (Zhang et al. 2017; Xie et al. 2017).