A study on the mutational landscape of B-LBL shows similar mutations to those in B-ALL, but genes associated with B-cell development, such as PAX5 and ETV6 are more common in B-ALL, while mutations in epigenetic regulators such as ARID1A, EP300, and KMT2D are more common in B-LBL [19]. The gene discussed is ETV6; the disease is precursor B-cell acute lymphoblastic leukemia.