The prognosis of pediatric ALCL, ALK + (65% to 85% 5-year OS) is similar to that in the adult counterpart and is worse than pediatric B-cell NHLs [9, 90]; the morphologic variant with small-sized tumor cells and/or lymphohistocytic background as well as minimal disseminated diseases in BM or PB are associated with increased treatment failure/relapse [91]. Here, ALK is linked to anaplastic large cell lymphoma.