To decipher whether HMOX1 was involved in the regulatory role of PTGDS on ferroptosis in PTCL, we performed lentiviral transfection to knockdown the expression of HMOX1 in PTCL cells, and the transfection efficiency was validated by western blotting (Fig. 8e). Here, HMOX1 is linked to mature T-cell and NK-cell non-Hodgkin lymphoma.