HMOX1 and mature T-cell and NK-cell non-Hodgkin lymphoma: Moreover, the regulatory role of AT56 on the expression of ferroptosis-associated and autophagy-associated proteins, and the accumulation of Fe2+ was reversed by HMOX1 knockdown in PTCL cells (Fig. 8g, h), indicating that HMOX1 played a key role in the positive effect of targeting PTGDS on iron metabolism and ferroptosis process in PTCL.