In-vitro and in-vivo experiments found that the increased level of ferroptosis enhanced by iron oxide nanoparticles and drug treatment, such as artesunate and imidazole ketone Erastin, could significantly inhibit the growth of DLBCL through inducing intracellular iron accumulation [45], lipid peroxidation and ferritinophagy [46], and impairing the STAT3 signaling pathway [47] in lymphoma. The gene discussed is STAT3; the disease is lymphoma.