Mechanically, the expression of ACSL4, the key factor in lipid metabolism, was decreased in PTCL cells with AT56 treatment and PTGDS knockdown (Fig. 6a, Supplementary Fig. S6A), indicating that targeting PTGDS promoted ferroptosis not through inducing lipid metabolism. The gene discussed is PTGDS; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.