BRCA1 and breast cancer: Consistent with this, alterations in BRCA1, BRCA2 and PALB2 were more prevalent in BCBM (7.8%, 5.5% and 2.7%) relative to BC (4.3%, 4.2% and 1.3%) and N-CNS metastases (3.2%, 4.9% and 1.3%).