Since CBL0137 has been recently shown to exert part of its anti-tumor activity by increasing CD8+ T-cell intratumor infiltration and activation in a murine model of colon carcinoma [31], we investigated whether CBL0137 anti-tumor activity in the 4T1.2 model is also at least partly dependent on modulation of adaptive immunity. This evidence concerns the gene CD8A and colon carcinoma.