Abnormal pale junctions characterized by repeating couplings, elongated desmosomes, and widened gaps in intercalated discs, typically observed in ARVC patients23, were detected in the myocardium of Pt-1, Pt-2, and Pt-3 (Figs. 4A–C). The gene discussed is ZNF77; the disease is arrhythmogenic right ventricular cardiomyopathy.