DSG2 and Ventricular arrhythmia: A cohort study evaluating genotype‒phenotype correlations in 1000 patients with HCM revealed 27 deleterious rare desmosomal variants, including DSG2 p.Arg119Ter, in 24 (2.4%) patients with HCM and demonstrated that deleterious rare desmosomal variants are associated with distinctive clinical features, including a higher incidence of RV involvement, ventricular arrhythmias, and conduction block32.