We also observed an increased expression of Cleaved PARP, P53, Cleaved caspase 9, Cleaved caspase 3 and BAX, as well as a reduced expression of BCL2 with the overexpression of SLC25A21. These results proved that SLC25A21 could inhibit the proliferation and induce apoptosis via activating the mitochondrial pathway in AML cells. Here, BCL2 is linked to acute myeloid leukemia.