TP53 and acute myeloid leukemia: We also observed an increased expression of Cleaved PARP, P53, Cleaved caspase 9, Cleaved caspase 3 and BAX, as well as a reduced expression of BCL2 with the overexpression of SLC25A21. These results proved that SLC25A21 could inhibit the proliferation and induce apoptosis via activating the mitochondrial pathway in AML cells.