CCK-8 assays showed that the overexpression of SLC25A21 inhibited the proliferation of Kasumi-1 and THP-1 cells, but the overexpression of CXCL8 reversed the SLC25A21-induced proliferation inhibition of AML cells (Fig. 6A, B). The gene discussed is CXCL8; the disease is acute myeloid leukemia.