TRAF6 and gastric cancer: First, we verified the high expression of TRAF6 in 5-FU-resistant GC cells (Fig. 1C, Supplementary Fig. 1A), then used GEPIA and Kaplan-Meier (KM) Plotter databases to detect positive correlation between aberrant TRAF6 activation and poor prognosis in GC patients (Fig. 1D).