CAV1 and neoplasm: Tumor samples from lovastatin-treated mice were characterized by reduced cellular necrosis, the disappearance of Cav-1, a CHO binding protein [69] that exerts a pro-tumorigenic role in RMS [[70], [71], [72], [73]], and by the reduction of pAkt1 [54], [76], [77], indicating that lovastatin-treated tumors were characterized by reduced malignancy.