In addition, altered alternatively splicing of the EPHB6 gene (located on chromosome 7q34 in the vicinity of the EPHA1 gene) has been associated with Alzheimer’s disease risk (82) and a rare autosomal EPHA6 copy number gain was found to co-segregate with familial Alzheimer’s disease status (83). This evidence concerns the gene EPHA1 and early-onset autosomal dominant Alzheimer disease.