LGI1 and encephalitis: Up to 90% of patients with anti-LGI1 encephalitis present with limbic encephalitis (LE) at some point in the disease, along with seizures and cognitive decline.24, 32, 33Faciobrachial dystonic seizures (FBDSs) are considered highly specific and frequently precede encephalitis, representing a window of opportunity for early diagnosis and treatment.34Multifocal seizures, including autonomic and pilomotor seizures, and hyponatremia are also tips for diagnosis.35