An adaptation of the AE diagnostic criteria algorithm was proposed to incorporate specific information for anti-NMDARE and anti-LGI1 encephalitis and to prevent misdiagnosis (Figure 2).8In this adaptation, possible AE is the entry criteria, followed by the sequential application of classical AE syndromes and acute disseminated encephalomyelitis (ADEM) criteria. The gene discussed is LGI1; the disease is encephalitis.