We also need further research to better understand the pathophysiological role of ambient temperature variations on BP, hypertension control, and cardiovascular disease burden by collecting precise individual-level data on heat exposure, water and electrolyte balance, RAAS, and antidiuretic hormone (ADH) response, along with continuous measurement of BP for better population-level intervention and clinical management of BP in response to global climate change. The gene discussed is AVP; the disease is cardiovascular disorder.