Most PCC/PGL patients with germline FH variantsbelong to retrospective cohorts of patients in whom HLRCC was not suspected beforethey were recruited, examined and tested; therefore, typical clinical manifestationsmight have been missed and pertinent family history may have not been collected.Similarly, patients may be lost to follow-up or may not be followed long enough, orthose who are not lost to follow-up may not be screened for uterine and cutaneousleiomyomas. Here, FH is linked to hereditary leiomyomatosis and renal cell cancer.