Some FH variants, however, have been described in patients withPCC/PGL and personal and/or family history of HLRCC-related manifestations, but notin those with isolated PCC/PGL, including c.349G>C (p.Ala117Pro),c.816_836del (p.Ala273_Val279del) and c.206G>A (p.Gly69Asp), and deletion ofthe entire coding sequence in one patient each. This evidence concerns the gene FH and hereditary leiomyomatosis and renal cell cancer.