Vascular endothelial growth factor (VEGF) is a highly conserved homologous dimer glycoprotein, whose gene is localized to human chromosome 6p21.3, and it is a specific factor promoting angiogenesis.[5] It is well known that angiogenesis is a key factor in the invasion and metastasis of malignant tumors, and VEGF plays a central role in this process.[6] Studies have shown that VEGF levels are significantly increased in a variety of malignant tumors (such as prostate cancer,[7] gastric cancer,[8] colorectal cancer,[9] etc) and are closely related to invasion and metastasis and poor prognosis. This evidence concerns the gene VEGFA and colorectal cancer.