BRAF and Langerhans cell histiocytosis: As BRAF is a pivotal kinase in the RAS-RAF-MEK signaling pathway, the BRAF-V600E mutation abrogates dendritic cell (DC) migration trap DCs in tissue lesions and causes evasion of apoptosis in LCH.[22]BRAF-V600E mutations have been reported in 38% to 57% of patients with nongastric LCH.[23,24] Among the 23 patients included in our present study and reported in the literature, 11 cases had been tested for BRAF V600E mutations and 10 had shown mutations.