HIF-1α is an important target for the treatment of brain hemorrhage.[25] Kim et al reported that in the process of vascular edema formation, PI3K/AKT may be a common downstream molecule of the TRPC3 and ETB receptor signal transduction pathways, and the PI3K/AKT signaling pathway may be an important therapeutic target pathway for vascular edema.[26] It is speculated that Mugua acts on targets such as TNF-α and VEGF, regulates the PI3K/AKT and HIF-1 signaling pathways, and plays a role in treating edema. This evidence concerns the gene VEGFA and intracranial hemorrhage.