Notably, the APOE alleles ε2 and ε4 are independently correlated with an increased risk of ICH.[5] Furthermore, cerebral amyloid angiopathy (CAA) exhibits a strong correlation with both advancing age and Alzheimer disease (AD).[6] In patients with AD, the administration of immunosuppressive therapy may elevate the risk of developing CAA.[7]. This evidence concerns the gene APOE and early-onset autosomal dominant Alzheimer disease.