SMAD3 and fibrosis: Ren et al[34] found through RNA-Seq transcriptomics that natural flavonoids pectinoaglytin can regulate the expression of related genes in kidney tissue by inhibiting the signaling pathway of TGF-β1 and transcription factors SMAD3 and STAT3, and alleviate renal tubulointerstitial fibrosis in HN mice and urate-treated mouse renal epithelial cells.