The median PSA was 93.60 ng/mL (range: 23.90–150 ng/mL) in the prostate cancer groups and 1.26 ng/mL (range: 0.18 3.88 ng/mL) in the BPH groups, there was statistical difference between 2 groups in PSA (P < .05). This evidence concerns the gene KLK3 and Familial prostate cancer.