Combined serum exosomes GAS5 with CEA, the AUC increases to 0.929, which showed better detection ability of early NSCLC compared to CEA only (AUC 0.718, sensitivity 50.37%, specificity 85%).[56] Another study showed a significant upregulation of exosomes lncRNA SOX2-OT in lung squamous cell carcinoma (LSCC) patients. This evidence concerns the gene SOX2 and non-small cell lung carcinoma.