Exosomal HOTAIR promote lung cancer proliferation, migration, and invasion by sponging miR-203.[52] In addition, GAS5-inficient exosomes original lung cancer cells could promote tumor angiogenesis.[53] MRPL23-AS1-enriched exosomes could promote lung metastasis via acting on pulmonary microvascular endothelial cells.[54]. This evidence concerns the gene HOTAIR and lung carcinoma.