TGFB1 and lung carcinoma: Wu et al[45] found that TGF-β mediated NSCLC derived exosomes lnc-MMP2-2 regulate the migration and invasion of lung cancer cells to blood vessels by up regulating the expression of vimentin and N-cadherin, reducing the expression of E-cadherin, and promoting the expression of matrix metalloproteinase 2.