SH‐SY5Y has been widely used in studies that focus on neurodegenerative diseases, as its differentiation with retinoic acid changes the cells' morphology such as increase of neuritic process, electrical excitability, and synaptophysin‐positive synapses, characteristics of cholinergic and dopaminergic neurons.31, 32. This evidence concerns the gene SYP and neurodegenerative disease.