Vaccines that prevent infections with the oncogenic viruses HBV and HPV have been successful in preventing hepatoma and HPV-associated cancers.45,46 Utilizing vaccines for cancer prevention is currently being explored in early-phase studies, including vaccines targeting KRAS mutations common in premalignant pancreatic lesions for patients at high risk for developing pancreatic cancer (NCT05013216) and TAAs for patients with Lynch syndrome at high risk for developing colon cancer (NCT05419011). The gene discussed is KRAS; the disease is cancer.