DLK1 and motor developmental delay due to 14q32.2 paternally expressed gene defect: DLK1 hypomethylation may be considered in patients with sporadic CPP, as in Temple syndrome [54, 55] where CPP has been ascribed to different methylation and expression of the maternal and paternal DLK1-DIO3 gene cluster, which is controlled by the imprinting control region IG-DMR [56].