Then, we used the 18 LUAD-driver genes reported by TCGA as seeds (ARID1A, BRAF, CDKN2A, EGFR, KEAP1, KRAS, MET, MGA, NF1, PIK3CA, RB1, RBM10, RIT10, SETD2, SMARCA4, STK11, TP53, and U2AF1) [60] and identified 251 neighbor genes in the embeddings of tumor and 505 neighbor genes in normal tissue. The gene discussed is PIK3CA; the disease is neoplasm.