TP53 and neoplasm: However, TP53 neighbor genes in tumor are enriched for functions related to tumor development, such as negative regulation of DNA replication (PBH = 0.02), 7-methylguanosine cap hypermethylation (PBH = 0.02), negative regulation of pentose-phosphate shunt (PBH = 0.02), and mitotic DNA damage checkpoint signaling (PBH = 0.03) (Fig. 7C).