Based on the gene expression data of the TCGA glioma patients, we calculated the TME cell infiltration levels according to the cell-type identification by estimating relative subsets of the RNA transcript (CIBERSORT) method [51] and found that macrophages (M0, M1, M2), CD8+ T cells, T follicular helper cells, and so on showed a significantly higher infiltration level in the class 1 subtype patients than that of the class 2 subtype patients (Supplementary Fig. S4A). This evidence concerns the gene CD8A and glioma.