In the context of ALD, where ABCD1 is predominantly present in astrocytes and microglia,10 ALD‐specific lipid dyshomeostasis in both cell types likely results in a combined effect on VLCFA accumulation within the central nervous system, thereby increasing the vulnerability of neurons to VLCFA toxicity. The gene discussed is ABCD1; the disease is X-linked adrenoleukodystrophy.