Univariate analysis indicated that cT staging (p < 0.001), HR status (p < 0.001), Ki‐67 (p < 0.001), HER2 expression (p < 0.001), cTNM staging (p = 0.010), molecular subtype (p < 0.001), and MetS (p = 0.012) were significantly associated with the pCR rate of patients after NAT. This evidence concerns the gene ERBB2 and metabolic syndrome.