Our study emphasizes the importance of CMDs (i.e., insufficient physical activity, obesity, diabetes, prediabetes, and stroke), inflammation, insulin‐related processes, cerebrovascular disease (i.e., greater SVD burden, particularly WMHs, lacunes, large infarcts, and white‐matter microstructural abnormalities) for deviations from “expected” CA, that is, BAG. The gene discussed is INS; the disease is diabetes mellitus.