Interestingly, a recent study of interrogating the interactomes of GSK3 using affinity purification and proximity-dependent biotinylation mass spectrometry indicates that GSK3 interacts with RTN1 (40), suggesting that RTN1 may mediate the pathogenic role of GSK3 in both DKD and in AKI-to-CKD transition. This evidence concerns the gene RTN1 and chronic kidney disease.