The shift in plasma substrate utilization from carbohydrates to lipids (i.e., free fatty acids [FFAs] and ketones) induced by SGLT2 inhibition via their glycosuric effect has been hypothesized to play a major role, as it possibly improves myocardial energy production and transduction, thereby delaying or preventing hospitalizations for HF (hHF) (8–16). Here, SLC5A2 is linked to hydrops fetalis.