Trophoblast stem cell‐derived exosomes may reduce ROS production and oxidative stress by delivering miR‐100‐5p, which downregulates the expression of NOX4, thereby ameliorating dopaminergic neuronal injury in Parkinson's disease model mice through the NOX4‐ROS‐Nrf2 pathway [176]. This evidence concerns the gene NOX4 and Parkinson disease.