As a vital member of the GPCR family, XCR1 can transmit signals by increasing intracellular calcium ion levels, and plays a critical role in dendritic‐cell‐mediated cytotoxic immune response, and in cancer cell proliferation and migration.[31, 32, 33] However, the function and regulatory mechanism of XCR1 in bone remain unclear. The gene discussed is XCR1; the disease is cancer.