XCR1 and osteoporosis: To evaluate the role of Xcr1 in osteoporosis in vivo, we performed ovariectomy (OVX) surgery in 3 months old female wild‐type (WT) mice, and utilized bone targeting AAV to overexpress Xcr1 (AAV‐DSS‐Xcr1) by intra‐articular injection (Figure6A).