Amyloid and tau pathology is not only correlated with more frequent and severe cases of NPS (Goukasian et al., 2019; Lopez-Jimenez et al., 2019; Youn et al., 2019; Babulal et al., 2022) but also may provide early markers for AD-associated NPS in the form of CSF levels of total tau (t-tau) and Aβ-42 (Babulal et al., 2022). This evidence concerns the gene MAPT and Alzheimer disease.