APP and Alzheimer disease: Other animal models, including APP-NLGF knock-in mice (Pugh et al., 2007), APOE4 (relative to APOE3) mice (Siegel et al., 2012; Taxier et al., 2022), TgF433-AD rats (Pentkowski et al., 2018), Wistar rats injected with intracerebroventricular streptozotocin to induce sporadic AD (Roy et al., 2022), and THY-Tau22 (which expresses human 4-repeat tau mutated at sites G272V and P301S under a Thy1.2-promotor) (Schindowski et al., 2006), also display increased anxiety-like behaviors.