Interestingly, considering that TrpC5 was previouslyshown to regulate P-gp expression in recipient cells, this study suggested thatTrpC5-enriched circulating EVs could promote cancer MDR development in these patients.More recently, Yang et al. [136] analyzed the levels of glutathione S-transferase P (GSTP1) mRNA inserum EVs from breast cancer patients treated with anthracycline/taxane-based neoadjuvantchemotherapy. This evidence concerns the gene PGP and breast cancer.