GPC1 and cancer: Melo et al. [89]reported that glypican-1 (GPC1) could be a specific marker of cancer-derived EVs and thatthe existence of GPC1-positive EVs in serum could differentiate patients with pancreaticductal adenocarcinoma (PDAC) from patients with benign pancreas disease or from healthycontrol subjects with 100% sensitivity and specificity.