However, the similarity of clinical signs with those seen in herpesvirus infections, the history of inflammatory stimulation with AAV8 administered IVT in other species, and the lack of significant differences in IL-10 levels between dose groups despite the difference in inflammation leads to the suggestion of future evaluation of a null viral vector (as previously described, producing no IL-10) and IL-10 protein control. Here, IL10 is linked to Herpesviridae infectious disease.