When the hourly data was collected into total, light and dark to check for differencesduring the activity phases, there was no difference between the genotypes for EE and RER (Supplementary Figures 1C, D).We investigated if the resistance to weight gain observed in Sult1a1 KOmice could provide protection against the harmful effects of diet induced obesity. The gene discussed is SULT1A1; the disease is obesity due to melanocortin 4 receptor deficiency.