The other studied mRNAs included CDH2 (AUC: 0.61 for DKD and 0.75 for overt DKD), MCP-1 (AUC: 0.61 for DKD and 0.66 for overt DKD), CCL21 (AUC: 0.888 for DKD and 1.0 for overt DKD), and ACE (AUC: 0.62 for DKD and 0.75 for overt DKD) (24, 27, 34). Here, ACE is linked to diabetic kidney disease.